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Börgeson Group

Emma Börgeson, PhD, Assistant Professor in Medicine, investigates the therapeutic potential of immunomodulation in obesity-related cardiometabolic pathophysiology. She aims to identify the underlying cause of metabolic disease and a more effective treatment targeting the inflammation that underlies pathophysiology.

The Börgeson lab is a translational research team, investigating the underlying disease mechanisms of obesity and cardiometabolic disease, with a special interest in inflammatory resolution.

Inflammation is a key driver of obesity-induced cardiometabolic pathophysiology and consists of two phases: an initial acute phase followed by a resolving phase. The latter is actively regulated by specialized pro-resolving lipid mediators (SPMs). Lipoxins are one group of SPMs that act through defined receptors to promote the resolution of inflammation.

The overall aim of the research is to investigate and harness the therapeutic potential of lipoxins. Her studies suggest that treatment with lipoxins attenuates obesity-induced adipose inflammation and subsequent development of systemic disease (Börgeson et al, Cell Metabolism, 2015). Her lab is currently investigating the underlying mechanisms that mediate this protection, and whether their results from preclinical models can be translated to human pathophysiology.

The team combines experimental studies with clinical basic research to address their hypothesis in a translational manner. The Börgeson lab uses ex vivo cultures of patient tissue biopsies, which provides valuable “proof-of-principle” evidence to correlate experimental data with human physiology. This translational approach requires state-of-the art experimental and clinical facilities, as well as a broad network of pre-clinical and clinical collaborators.

Dr. Börgeson trained at Linköping University in Sweden, University College Dublin in Ireland, and the University of California San Diego in USA, before joining Gothenburg University in 2016. Her research resulted in numerous publications in top journals. In addition, Dr. Börgeson received several awards in recognition of her scientific work, including the VR and SSMF establishment award and several Young Investigator and Emerging Leader Awards.

National and International Collaborations

The Börgeson laboratory collaborates with several clinical platforms in Gothenburg, including Dr. Ville Wallenius and Dr. Lars Fändriks at the Department of Surgery, Sahlgrenska Hospital, as well as the “Surgical Oncology Laboratory” and the “Fibrinolys Laboratory”. At the Wallenberg Laboratory, Dr Börgeson collaborates with leading Swedish scientists Dr. Jan Borén and Dr. Fredrik Bäckhed. Other national collaborations are established with Dr. Lena Jonasson and Dr. Robert Blomgran at the University of Linköping, as well as research staff at Uppsala University and the SciLifeLab national resource for molecular biosciences.

In addition, Dr. Börgeson has several international collaborations with leading scientists in the field. These include the University of California San Diego, University of California Davis, University College Dublin and the University College London.

Dr. Börgeson was recently awarded a Pilot Project Grant from the National Institutes of Health, in collaboration with Dr. Lange at UC San Diego. This pilot project established a collaboration with the West Coast Metabolomics Center at UC Davis, to investigate changes to the lipid metabolome in patient plasma samples.

Research Opportunities in the Laboratory

​We are currently recruiting post-docs, PhD students, registered nurses and lab technicians. For more information please contact emma.borgeson@gu.se

Contact Information

Emma Börgeson

Wallenberglaboratoriet, Sahlgrenska University Hospital Blå Stråket 5, 413 45, Gothenburg

Visiting Address:
Sahlgrenska University Hospital Blå Stråket 5, Elevator H, level 2/3

Delivery address:
Wallenberglaboratoriet, Lab 7, Bruna Stråket 16, 413 45 Göteborg, Sweden

+46 31 342 38 33 (office)
+46 31 342 94 83 (lab)

emma.borgeson@gu.se

 

Page Manager: Pontus Sundén|Last update: 6/26/2017
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