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Michael Schöll Group

Michael Schöll, PhD, is an Associate Senior Lecturer (Assistant Professor) in molecular medicine with focus on neuroimaging. His research aims to identify, using neuroimaging, neuropathological changes that differentiate a brain that will eventually develop a neurodegenerative disease such as a dementia disorder from a brain that will age healthily at the earliest possible stage.

Research summary

Neurodegenerative diseases are still notoriously difficult to diagnose early and there is still no cure available for dementia disorders such as Alzheimer’s disease (AD). Biomarkers derived from imaging modalities such as positron emission tomography (PET) and magnetic resonance imaging (MRI), as well as biomarkers based on the analysis of cerebrospinal fluid (CSF) or blood, have become immensely important especially for the early identification of individuals who are likely to develop a neurodegenerative disorders, since an established notion is that potentially successful treatments should be deployed as early as possible in the disease process.

This early identification of neuropatholigical processes using adequate biomarkers currently not only supports reliable clinical diagnoses but also serves the recruitment of suitable candidates for clinical treatment trials, and renders possible the application of these biomarkers as outcome measures in treatment trials.

In particular the recent development of methods to map the accumulation of conformationally faulty forms of proteins and the subsequent synaptic impairment in vivo using PET has profoundly changed the way these processes can be identified at an early, presymptomatic disease stage. The Schöll group is using the most recent developments in molecular imaging by means of PET in combination with other neuroimaging- and fluid-based biomarkers, as well as neuropsychological profiling to develop holistic, validated, and usable tools for such an early identification.

Collaborations

The establishment of the Schöll group was strongly coupled with the recent inauguration of the Imaging- and Intervention Center (Bild- och Interventionscentrum – BoIC) at the Sahlgrenska University Hospital, which for the first time offers resources for research involving molecular imaging modalities in West Sweden.

The group has furthermore established extensive collaborations with researchers and clinicians at the University of Gothenburg / The Sahlgrenska University Hospital, and with researchers at Lund University and the Karolinska Institute. Internationally, the group collaborates actively with researchers at the University of California, Berkeley, the University of California, San Francisco, Stanford University, and the VU Medical Center in Amsterdam.

Page Manager: Pontus Sundén|Last update: 5/12/2017
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Denna text är utskriven från följande webbsida:
http://wcmtm.gu.se/research-groups/scholl/
Utskriftsdatum: 2017-11-21