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Jeremie Boucher Group

 Jeremie Boucher, PhD, Adjunct Senior Lecturer (Associate Professor), aims to identify novel targets and pathways for the treatment of obesity and type 2 diabetes. He is also employed as a Principal Scientist at AstraZeneca, where he is coordinating and driving the early discovery programs for the treatment of metabolic diseases. This constitutes a unique opportunity to quickly translate the research findings of his lab into potential medicine to improve patients’ life.

Adipose tissue plays a central role in the development of insulin resistance and diabetes. The Boucher lab is working on modulating adipose tissue phenotype for the treatment of metabolic diseases:

1) Increasing brown adipose tissue abundance or activity or converting white into brown adipocytes holds promise for the treatment of metabolic diseases. We are characterizing the molecular pathways controlling the development, differentiation and function of white, beige and brown adipose cells, and the role that BMPs and the transcription factors PPARa and g play in those processes

2) Senescence (aging of cells) of adipose tissue is closely associated with common cardiometabolic complications including type 2 diabetes and cardiovascular diseases. We are investigating the key drivers of senescence in the different adipose tissue cells (endothelial cells, mesenchymal stem cells, adipocytes) in metabolic diseases, how senescent cells communicate with other cells and tissues to impact metabolism, and how to inhibit senescence in adipose

International Collaborations

Jeremie Boucher has an extensive national and international collaboration network with researchers from Harvard Medical School, University of Pennsylvania, University of Virginia, University of Campinas, INSERM, the Novo Nordisk Foundation Center for Basic Metabolic Research, and the Integrated Cardio Metabolic Centre/Karolinska Institute

 

Contact Information

Jeremie Boucher

jeremie.boucher@gu.se
Jeremie.Boucher@astrazeneca.com

Visiting addresses:
The Lundberg Laboratory for Diabetes Research
Blå Stråket 5,
Sahlgrenska University Hospital,
SE-413 45 Göteborg

Astrazeneca
Pepparedsleden 1,
SE-431 50 Mölndal

Page Manager: Mattias Lindgren|Last update: 1/31/2019
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