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Anetta S. Härtlova lab

Molecular mechanisms of innate immune signalling

Anetta S. Härtlova, PhD, is an Assistant Professor in Molecular Medicine with main focus on understanding the role and regulation of immune and inflammatory pathways – that protect against pathogen infection but also contribute to chronic inflammation – in the context of ageing and age-related pathologies. Her research aims to explore the molecular regulation of these pathways in order to develop new therapeutic target against chronic inflammation and ageing.

Research summary

Recently, chronic inflammation has been recognized as one of the hallmarks of the ageing process and the age-related diseases including neurodegeneration and metabolic disorders. However, little is known about the causes and molecular mechanisms that mediate systemic chronic inflammation. There is an increasing appreciation that changes in the tissue microenvironment, such as the accumulation of cell debris and systemic changes in metabolic and hormonal signals, contribute to macrophage polarization and the development of chronic inflammation. Despite its relevance, there is little understanding of the cellular and molecular mechanisms underlying macrophages’ plasticity required for tissue homeostasis.

The main research interest of the laboratory is to examine the cell type-specific roles of phagocytosis and innate immune sensing pathways in the regulation of inflammatory response using a combination of biochemical, high-resolution mass spectrometry, and image-based approaches in vitro and in conditional knockout mouse models. Our long term goal is to develop therapeutic strategies to modulate these pathways and prevent or treat age-related human diseases.

Collaborations

The group has furthermore established extensive collaborations with researchers at the University of Gothenburg and Umeå University. Internationally, the group collaborates actively with researchers at Newcastle University (U.K.), Francis Crick Institute London (U.K.), Imperial College London (U.K.), Weizmann Institute of Science (Israel), VIB Ghent (Belgium), Institute Pasteur de Lille (France) and Medical Faculty, University of Chile (Chile).

Contact Information

Anetta Svitorka Härtlova

anetta.hartlova@gu.se

Postal Address: Box 435, 40530 Göteborg
Visiting Address: Medicinaregatan 7 A
40530 Göteborg

Department of Microbiology and Immunology at Institute of Biomedicine
Box 435
405 30 Göteborg

Visiting Address: Medicinaregatan 7 A
405 30 Göteborg

Page Manager: Mattias Lindgren|Last update: 10/9/2018
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