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Key Publications

Annika S Axelsson, Emily Tubbs, Brig Mecham, Shaji Chacko, Hannah A Nenonen, Yunzhao Tang, Jed W Fahey, Jonathan MJ Derry, Claes B Wollheim, Nils Wierup, Morey W Haymond, Stephen H Friend, Hindrik Mulder, AH Rosengren
Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes
Science Translational Medicine, 9, eaah4477, 2017 http://stm.sciencemag.org/content/9/394/eaah4477

Axelsson AS, Mahdi T, Nenonen HA, Hänzelmann S, Bagge A, Wendt A, Reinbothe TM, Millstein J, Yang X, Zhang B, Gusmao EG, Shu L, Tang Y, Wang J, Andersson SE, Eliasson L, Artner I, Wollheim CB, Derry JM, Mecham B, Spégel P, Mulder H, Gesteira Costa Filho I, Zhang E, Rosengren AH
Sox5 regulates adult beta-cell phenotype and is reduced in type 2 diabetes
Nature Communications, 15652, 2017. https://www.nature.com/articles/ncomms15652

Tang Y, Axelsson A, Spegel P, Andersson LE, Mulder H, Groop L, Renström E, Rosengren AH
Genotype-based treatment of type 2 diabetes with an alpha2A-adrenergic receptor antagonist
Science Translational Medicine Oct 2014.

Mahdi T, Hänzelmann S, Salehi A, Muhammed SJ, Reinbothe TM, Tang Y, Axelsson AS, Zhou Y, Jing X, Almgren P, Krus U, Taneera J, Blom AM, Lyssenko V, Esguerra JLS, Hansson O, Eliasson L, Derry J, Zhang E, Wollheim CB, Groop L, Renström E, Rosengren AH.
Secreted Frizzled-Related Protein 4 Reduces Insulin Secretion and Is Overexpressed in Type 2 Diabetes.
Cell Metabolism 3;16:625-33. 2012.

Rosengren AH, Braun M, Mahdi T, Andersson SA, Travers ME, Shigeto M, Zhang E, Almgren P, Ladenvall C, Axelsson AS, Edlund A, Gram Pedersen M, Jonsson A, Ramracheya R, Tang Y, Walker JN, Barrett A, Johnson PRV, Lyssenko V, McCarthy MI, Groop L, Salehi A, Gloyn AL, Renström E, Rorsman P and Eliasson L.
Reduced insulin exocytosis in human pancreatic beta-cells with gene variants linked to type-2 diabetes.
Diabetes 61(7):1726-33. 2012.

Rosengren AH, Jokubka R, Tojjar D, Granhall C, Hansson O, Li DQ, Nagaraj V, Reinbothe TM, Tuncel J, Eliasson L, Rorsman P, Salehi A, Groop L, Lyssenko V, Luthman H, Renström E.
Overexpression of alpha2A-adrenergic receptors contributes to type 2-diabetes.
Science 327:217. 2010.

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